The phylogenetic range of bacterial and viral pathogens of vertebrates

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dc.contributor.authorShaw, Liam P.
dc.contributor.authorWang, Alethea D.
dc.contributor.authorDylus, David
dc.contributor.authorMeier, Magda
dc.contributor.authorPogacnik, Grega
dc.contributor.authorDessimoz, Christophe
dc.contributor.authorBalloux, François
dc.date.accessioned2020-06-15T10:33:29Z
dc.date.available2020-06-15T10:33:29Z
dc.date.copyright2020
dc.date.issued2020-09-01
dc.descriptionThis article is licensed under Creative Commons License and full text is openly accessible in CUD Digital Repository. The version of the scholarly record of this article is published in Molecular Ecology (2020), accessible online through this link https://doi.org/10.1111/mec.15463en_US
dc.description.abstractMany major human pathogens are multihost pathogens, able to infect other vertebrate species. Describing the general patterns of host–pathogen associations across pathogen taxa is therefore important to understand risk factors for human disease emergence. However, there is a lack of comprehensive curated databases for this purpose, with most previous efforts focusing on viruses. Here, we report the largest manually compiled host–pathogen association database, covering 2,595 bacteria and viruses infecting 2,656 vertebrate hosts. We also build a tree for host species using nine mitochondrial genes, giving a quantitative measure of the phylogenetic similarity of hosts. We find that the majority of bacteria and viruses are specialists infecting only a single host species, with bacteria having a significantly higher proportion of specialists compared to viruses. Conversely, multihost viruses have a more restricted host range than multihost bacteria. We perform multiple analyses of factors associated with pathogen richness per host species and the pathogen traits associated with greater host range and zoonotic potential. We show that factors previously identified as important for zoonotic potential in viruses—such as phylogenetic range, research effort, and being vector-borne—are also predictive in bacteria. We find that the fraction of pathogens shared between two hosts decreases with the phylogenetic distance between them. Our results suggest that host phylogenetic similarity is the primary factor for host-switching in pathogens. © 2020 The Authors. Molecular Ecology published by John Wiley & Sons Ltden_US
dc.description.sponsorshipEuropean Research Council Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschungen_US
dc.identifier.citationShaw, L. P., Wang, A. D., Dylus, D., Meier, M., Pogacnik, G., Dessimoz, C., & Balloux, F. (2020). The phylogenetic range of bacterial and viral pathogens of vertebrates. Molecular Ecology, 29(17), 3361-3379. https://doi.org/10.1111/mec.15463en_US
dc.identifier.issn09621083
dc.identifier.urihttps://doi.org/10.1111/mec.15463
dc.identifier.urihttp://hdl.handle.net/20.500.12519/219
dc.language.isoenen_US
dc.publisherBlackwell Publishing Ltden_US
dc.relationAuthors Affiliations : Shaw, L.P., UCL Genetics Institute, University College London, London, United Kingdom, Nuffield Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom; Wang, A.D., UCL Genetics Institute, University College London, London, United Kingdom, Canadian University Dubai, Dubai, United Arab Emirates; Dylus, D., Department of Computational Biology, University of Lausanne, Lausanne, Switzerland, Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland, Swiss Institute of Bioinformatics, Lausanne, Switzerland; Meier, M., UCL Genetics Institute, University College London, London, United Kingdom, Genetics and Genomic Medicine, University College London Institute of Child Health, London, United Kingdom; Pogacnik, G., UCL Genetics Institute, University College London, London, United Kingdom; Dessimoz, C., Department of Computational Biology, University of Lausanne, Lausanne, Switzerland, Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland, Swiss Institute of Bioinformatics, Lausanne, Switzerland, Department of Genetics Evolution and Environment, Centre for Life's Origins and Evolution, University College London, London, United Kingdom, Department of Computer Science, University College London, London, United Kingdom; Balloux, F., UCL Genetics Institute, University College London, London, United Kingdom
dc.relation.ispartofseriesMolecular Ecology; Volume 29, Issue 17
dc.rightsCreative Commons Attribution 4.0 International (CC BY 4.0)
dc.rights.holderCopyright : © 2020 The Authors. Molecular Ecology published by John Wiley & Sons Ltd
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectemerging infectious diseasesen_US
dc.subjectphylogeneticsen_US
dc.subjectzoonotic diseasesen_US
dc.subjecthost jumpsen_US
dc.subjecthost rangeen_US
dc.titleThe phylogenetic range of bacterial and viral pathogens of vertebratesen_US
dc.typeArticleen_US
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