Li, YiLi, XuanIssa, SaharOmar, Khairi Mohamed2021-06-162021-06-1620212021-07Li, Y., Li, X., Issa, S., & Omar, K. M. (2021). Effects of Radiotherapy in Patients with Nasopharyngeal Carcinoma under Continuous-discrete Mixed Mathematical Model and Comparison on the Fungal and Pathogen Infection Indexes Before and After Nutritional Supplementation. Results in Physics, 26, 104355. https://doi.org/10.1016/j.rinp.2021.10435522113797https://doi.org/10.1016/j.rinp.2021.104355http://hdl.handle.net/20.500.12519/390The study aimed to explore the effects of radiotherapy on nasopharyngeal carcinoma (NPC) patients before and after nutritional supplementation, and the correlation between nutritional supplementation and infections, using continuous-discrete mixed mathematical model. Specifically, 398 NPC patients were selected based on information and health data. They all accepted radiation therapy, and enteral nutrition was provided through nasal feeding during the radiotherapy. Then, nutritional indicators, and infections were compared before and after nutritional supplementation. The results showed that, the radio-sensitivity coefficient and the age of tumor cells affected radiotherapy effects. After nutritional supplementation, the patient's Hemoglobin (Hb) was 139.26 ± 12.87 g/L, the serum albumin (ALB) was 45.65 ± 3.84 g/ L, the Lymphocyte (LYM) was 1.96 ± 0.68 (×109/L), and the Body Mass Index (BMI) was 26.12 ± 2.63 (kg/m2). Among them, Hb, LYM, and BMI were notably different from those before treatment (P < 0.05). After nutritional supplementation, the infection rates of Candida albicans, Candida tropicalis, Saccharomyces cerevisiae, Candida, and actinomycetes were reduced to 26.09%, 17.39%, 9.78%, 5.43%, and 1.09%, respectively, showing notable differences (P < 0.05); the infection rates of Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, pyogenic chain Coccus, Staphylococcus epidermidis, and Streptococcus viridans were reduced to 15.27%, 12.21%, 3.82%, 6.11%, 0.76%, and 0.76%, respectively, showing notable differences (P < 0.05). In conclusion, the continuous-discrete mixed mathematical model can simulate the effects of radiotherapy on NPC patients. Nutritional supplementation during radiotherapy can reduce the infection rates, thus improving the prognosis of NPC patients. © 2021 The Author(s)enCreative Commons CC-BY-NC-ND LicenseComputer information health dataContinuous-discrete mixed mathematical modelFungal and pathogen infectionNasopharyngeal carcinamaArticleCopyright : © 2021 The Author(s)