Effects of radiotherapy in patients with nasopharyngeal carcinoma under continuous-discrete mixed mathematical model and comparison on the fungal and pathogen infection indexes before and after nutritional supplementation

dc.contributor.authorLi, Yi
dc.contributor.authorLi, Xuan
dc.contributor.authorIssa, Sahar
dc.contributor.authorOmar, Khairi Mohamed
dc.descriptionThis article is licensed under Creative Commons License and full text is openly accessible in CUD Digital Repository. The version of the scholarly record of this article is published in Results in Physics (2021), accessible online through this link https://doi.org/10.1016/j.rinp.2021.104355en_US
dc.description.abstractThe study aimed to explore the effects of radiotherapy on nasopharyngeal carcinoma (NPC) patients before and after nutritional supplementation, and the correlation between nutritional supplementation and infections, using continuous-discrete mixed mathematical model. Specifically, 398 NPC patients were selected based on information and health data. They all accepted radiation therapy, and enteral nutrition was provided through nasal feeding during the radiotherapy. Then, nutritional indicators, and infections were compared before and after nutritional supplementation. The results showed that, the radio-sensitivity coefficient and the age of tumor cells affected radiotherapy effects. After nutritional supplementation, the patient's Hemoglobin (Hb) was 139.26 ± 12.87 g/L, the serum albumin (ALB) was 45.65 ± 3.84 g/ L, the Lymphocyte (LYM) was 1.96 ± 0.68 (×109/L), and the Body Mass Index (BMI) was 26.12 ± 2.63 (kg/m2). Among them, Hb, LYM, and BMI were notably different from those before treatment (P < 0.05). After nutritional supplementation, the infection rates of Candida albicans, Candida tropicalis, Saccharomyces cerevisiae, Candida, and actinomycetes were reduced to 26.09%, 17.39%, 9.78%, 5.43%, and 1.09%, respectively, showing notable differences (P < 0.05); the infection rates of Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, pyogenic chain Coccus, Staphylococcus epidermidis, and Streptococcus viridans were reduced to 15.27%, 12.21%, 3.82%, 6.11%, 0.76%, and 0.76%, respectively, showing notable differences (P < 0.05). In conclusion, the continuous-discrete mixed mathematical model can simulate the effects of radiotherapy on NPC patients. Nutritional supplementation during radiotherapy can reduce the infection rates, thus improving the prognosis of NPC patients. © 2021 The Author(s)en_US
dc.identifier.citationLi, Y., Li, X., Issa, S., & Omar, K. M. (2021). Effects of Radiotherapy in Patients with Nasopharyngeal Carcinoma under Continuous-discrete Mixed Mathematical Model and Comparison on the Fungal and Pathogen Infection Indexes Before and After Nutritional Supplementation. Results in Physics, 26, 104355. https://doi.org/10.1016/j.rinp.2021.104355en_US
dc.publisherElsevier B.V.en_US
dc.relationAuthors Affiliations : Li, Y., Department of Otolaryngology, the 988th Hospital of the Joint Support Force of the Chinese People's Liberation Army, Zhengzhou City 450042, Henan Province, China; Li, X., Laboratory of Blood Transfusion, 988th Hospital of Chinese PLA, Zhengzhou City 450042, Henan Province, China; Issa, S., Department of Environmental Health Sciences, Faculty of Communication, Arts and Sciences, Canadian University Dubai, Dubai, United Arab Emirates; Omar, K.M., Applied Science University, Al Eker, Bahrain
dc.relation.ispartofseriesResults in Physics;Volume 26
dc.rightsCreative Commons CC-BY-NC-ND License
dc.rights.holderCopyright : © 2021 The Author(s)
dc.subjectComputer information health dataen_US
dc.subjectContinuous-discrete mixed mathematical modelen_US
dc.subjectFungal and pathogen infectionen_US
dc.subjectNasopharyngeal carcinamaen_US
dc.titleEffects of radiotherapy in patients with nasopharyngeal carcinoma under continuous-discrete mixed mathematical model and comparison on the fungal and pathogen infection indexes before and after nutritional supplementationen_US
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