Browsing by Author "Issa, Sahar"
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Item Effects of radiotherapy in patients with nasopharyngeal carcinoma under continuous-discrete mixed mathematical model and comparison on the fungal and pathogen infection indexes before and after nutritional supplementation(Elsevier B.V., 2021-07) Li, Yi; Li, Xuan; Issa, Sahar; Omar, Khairi MohamedThe study aimed to explore the effects of radiotherapy on nasopharyngeal carcinoma (NPC) patients before and after nutritional supplementation, and the correlation between nutritional supplementation and infections, using continuous-discrete mixed mathematical model. Specifically, 398 NPC patients were selected based on information and health data. They all accepted radiation therapy, and enteral nutrition was provided through nasal feeding during the radiotherapy. Then, nutritional indicators, and infections were compared before and after nutritional supplementation. The results showed that, the radio-sensitivity coefficient and the age of tumor cells affected radiotherapy effects. After nutritional supplementation, the patient's Hemoglobin (Hb) was 139.26 ± 12.87 g/L, the serum albumin (ALB) was 45.65 ± 3.84 g/ L, the Lymphocyte (LYM) was 1.96 ± 0.68 (×109/L), and the Body Mass Index (BMI) was 26.12 ± 2.63 (kg/m2). Among them, Hb, LYM, and BMI were notably different from those before treatment (P < 0.05). After nutritional supplementation, the infection rates of Candida albicans, Candida tropicalis, Saccharomyces cerevisiae, Candida, and actinomycetes were reduced to 26.09%, 17.39%, 9.78%, 5.43%, and 1.09%, respectively, showing notable differences (P < 0.05); the infection rates of Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, pyogenic chain Coccus, Staphylococcus epidermidis, and Streptococcus viridans were reduced to 15.27%, 12.21%, 3.82%, 6.11%, 0.76%, and 0.76%, respectively, showing notable differences (P < 0.05). In conclusion, the continuous-discrete mixed mathematical model can simulate the effects of radiotherapy on NPC patients. Nutritional supplementation during radiotherapy can reduce the infection rates, thus improving the prognosis of NPC patients. © 2021 The Author(s)Item Postoperative drug-resistant bacteria infection in patients with acute Stanford type A aortic dissection under two-fluid numerical simulation model(Elsevier B.V., 2021-07) Zang, Sheng; Zhang, Yu; Xu, Jiarui; Du, Yaming; Issa, Sahar; Al Dulaimi, Saeed Hameed KurdiObjective: This study was to investigate the characteristics and related factors of postoperative drug-resistant bacteria infection (DRBI) in patients with acute Stanford A aortic dissection (AD) (AAAD) based on a two-fluid numerical simulation model (TFNS model). Methods: 50 patients with AAAD admitted to our hospital from July 2018 to October 2020 were selected as the research objects. The patients were rolled into an infection group and a non-infection group according to whether DRBI occurred after surgery. There were 21 patients in the infected group and 29 patients in the non-infected group. The clinical data of the patients were collected, including preoperative, intraoperative, and postoperative conditions. A TFNS model was constructed. The construction of vascular physical model could be completed by the construction of fluid area and solid area. The blood flows through the fluid area and the blood vessel wall was located in the solid area. The model was adopted to study the characteristics of DRBI. The data of the patients were analyzed to explore the relationship of the multi-DRBI to intraoperative blood loss, postoperative complications, intensive care unit (ICU) stay time, invasive procedures, and use of antibiotics. In addition, the multi-factor postoperative multi-DRBI was performed with the regression analysis. Results: There was no significant difference between the infected group and the non-infected group in antibiotics used such as cephalosporin, penicillin, glycopeptide, and quinolones (P > 0.05). The time spent on antibiotics was greatly lower in the infected group than in the non-infected group (P < 0.05). The ICU stay time in the infected group was 17.78 ± 11.55, and that in the non-infected group was 6.67 ± 4.36, without notable difference between the two groups (P < 0.05). In addition, there was no significant difference between the two groups in the time to transfer to the ICU, while there was one case infected with Staphylococcus aureus, Pseudomonas aeruginosa, and Enterobacter cloacae. The excessive plasma loss (odds ratio (OR) = 3.823, 95% confidential interval (CI) = 1.643–8.897), renal insufficiency (OR = 1.855, 95% CI = 1.076–3.199), ICU stay time (OR = 5.089, 95% CI = 1.507–17.187), indwelling time of nasal feeding tube (NFT) (OR = 3.225, 95% CI = 1.332–7.807), assisted ventilation (OR = 3.077, 95% CI = 1.640–5.773), tracheal intubation (OR = 5.078, 95% CI = 1.415–18.227), tracheotomy (OR = 0.073, 95% CI = 0.013–0.382), continuous renal replacement (CRR) therapy (OR = 0.111, 95% CI = 0.023–0.476), use time of antibiotics (OR = 1.089, 95% CI = 1.038–1.143) were independent risk factors for postoperative multi-DRBI. Conclusion: postoperative multi-DRBI was characterized by Acinetobacter baumannii infection with the largest proportion, followed by Klebsiella pneumoniae; excessive plasma loss, renal insufficiency, ICU stay time, indwelling time of NFT, assisted ventilation, tracheal intubation, tracheotomy, CRR therapy, and use time of antibiotics were all independent risk factors of postoperative multi-DRBI. In the postoperative care of AAAD patients, the inducing factors had to be informed to the patient, and relative measures should be taken to prevention and treatment, which was conductive to reducing the incidence of infection and promote the recovery of AAAD. © 2021 The Author(s)Item Prediction of epidemiological characteristics of vascular cognitive impairment using SIR mathematical model and effect of brain rehabilitation and health measurement system on cognitive function of patients(Elsevier B.V., 2021-06) Hu, Yanqun; Zhong, Wei; Cen, Yunguang; Han, Shuyan; Feng, Zhiyun; Zhang, Xuri; Li, Wei; Wang, Lanhua; Li, Bin; Issa, Sahar; Ismail, Ragab IbrahimThe purpose is to explore the prediction of epidemiological characteristics of vascular cognitive impairment based on susceptible infectious recovered and immune hosts (SIR) mathematical model and the effect of brain rehabilitation health measurement system on cognitive function of patients. SIR mathematical model was used to predict the epidemiological characteristics of vascular cognitive impairment (VCIND). Then, 60 patients with non dementia vascular cognitive impairment were randomly divided into training group and control group. Both groups were given conventional drug therapy and traditional rehabilitation training. The training group increased brain rehabilitation on this basis. Health measurement system cognitive training, 40 min/time, once a day, 5 times a week for a total of 4 weeks. A simple intelligent mental scale (MMSE), Montreal Cognitive Assessment Scale (MoCA), Barthel Index (BI), and myoelectric evoked potentiometer were used for cognitive function, daily life activity (ADL) ability, and P300 of two groups of patients. assessment. The purpose of this study was to investigate the effects of brain rehabilitation health care measurement system-assisted cognitive training on cognitive function and event-related potential (ERP) P300 in patients with VCIND. The study found that the brain rehabilitation health care measurement system assisted cognitive training can effectively improve the cognitive function of patients with VCIND and their daily activities. © 2021 The AuthorsItem The experience of ER nurses in Lebanese hospitals, during the Covid-19 outbreak: a qualitative study(Cambridge University Press, 2023-01-04) Chaiban, Cedric Georges; Maamari, Olivia; Issa, Sahar; Kosremelli Asmar, MichèleOBJECTIVE: The increasing number of Covid-19 cases, as well as the overwhelming workload, constitute a serious occupational health threat to Emergency Room (ER) nurses working on the frontlines. In Lebanon, where unstable socio-economic conditions reign, the Covid-19 outbreak was added to the plethora of daily challenges faced by the healthcare workers. The study's objective is to explore how Lebanese ER nurses perceived their duty on the frontlines amid the Covid-19 pandemic. METHODS: This study has a descriptive exploratory qualitative design. Fifteen Lebanese ER nurses working directly with Covid-19 patients were recruited from three university hospitals in Beirut. Interviews were held for data collection until data saturation. Subsequent analysis was done via coding of the transcribed verbatim. RESULTS: The findings showed significant gaps related to preparedness, support and governmental action. Similarly, the frontliners faced serious challenges that increased their stress levels both physically and mentally. Furthermore, some participants were subject to stigma and had to face irresponsible behaviors during triage. Participants emphasized the need to guarantee a safe environment at work, to provide Covid-19 patients with the needed care. CONCLUSIONS: ER nurses struggled during this pandemic while working on the frontlines. They described their experience as not satisfying, with high levels of stress, danger and challenges. © 2023 Society for Disaster Medicine and Public Health, Inc.